Abstract

Enteric-coated mycophenolate mofetil: role in transplantation

Author(s): Maurizio Salvadori and Elisabetta Bertoni

This review outlines the mechanism of action of mycophenolic acid in transplantation. Its main side effects (gastrointestinal) often lead to dose reduction or discontinuation, which in turn carry the risk of graft failure. To overcome this problem, an enteric-coated version of mycophenolic acid has been developed. The authors, after having discussed the pharmacokinetics and pharmacodynamics of the compound, will review the main multinational trials. Finally, recent findings not yet published concerning the compound have been examined, as well as the possible use in nonrenal transplantation.