Abstract

Neurological Improvement with Medical Cannabis in a Progressive Supranuclear Palsy Patient: A Case Report

Author(s): Ana Hounie, Marco Agassiz

Statement of the Problem: Progressive supranuclear palsy (PSP) is a severe, debilitating, and often fatal disease resembling other neurodegenerative disorders, namely Alzheimer’s (AD) and Parkinson’s (PD) diseases, which have been successfully treated with cannabinoids. Methodology & Theoretical Orientation: we herein report the case of a 71-year-old woman diagnosed with PSP, displaying severe impairment of motor and language functions which progressively improved after treatment with medical cannabis. The possible mechanisms of this improvement are discussed Findings: Before treatment, the patient was unable to move her limbs, was fed soft food, and was unable to speak or move her eyes. The patient has regained horizontal eye movement, is able to walk with assistance, has returned to physiotherapy, started to eat solid food, and has had a remarkable improvement in her speech. Conclusion & Signifi cance: PSP has very limited treatment response with the current traditional treatments. We had great response with medical cannabis. The possible mechanisms of this improvement are discussed.