Abstract

Niosomal Drug Delivery

Author(s): Anette Jacobs

Noisy vesicles, also known as non-ionic surfactant vesicles, are microscopic lamellar structures formed when a nonionic surfactant of the alkyl or dialkyl polyglycerol ether class is combined with cholesterol and hydrated under aqueous circumstances. They’re vesicular structures that resemble liposomes and are capable of transporting both amphiphilic and lipophilic drugs. The basic synthesis mechanism is the same: the lipid phase is hydrated by an aqueous phase, which can be either a pure surfactant or a surfactant-cholesterol mixture. Dialysis centrifugation or gel filtration is used to extract entrapped medicines from liposomal dispersion.