Abstract

Protective effect of sacubitril valsartan on acute kidney injury in patients with acute decompensated heart failure

Author(s): Gonghao Li, Jiakun Tian, Yunfeng Zhao

The interactions between the heart and kidneys are complex and a subject of great clinical and scientific interest and debate. Acute Decompensated Heart Failure (ADHF) represents the principal cause of hospitalization for Heart Failure (HF), with a prevalence that increases with age and contributes significantly to healthcare costs. Acute Kidney Injury (AKI) represents a significant adverse event among patients with ADHF, with a considerable impact on morbidity. In more than 30% of cases of ADHF, AKI develops during the course of the patient’s hospitalization. The occurrence of new-onset AKI in patients with HF was associated with an elevated risk of in-patient mortality, prolonged length of stay, and increased healthcare costs compared to HF hospitalizations in which patients did not develop AKI. The management of HF in the setting of new-onset AKI represents a significant medical challenge in the acute setting due to the complex relationship between the cardiovascular and renal systems. The early detection of AKI in patients with ADHF and the implementation of appropriate interventions are of paramount importance in order to reduce the mortality rate of patients with AKI and to save money for the health insurance department. The aim of the current work is to identify effective interventions and future treatments for patients with ADHF and AKI.