Abstract

The Role of Biologics in Rheumatoid Arthritis: Efficacy and Safety

Author(s): Lucas Martinez*

Rheumatoid arthritis (RA) is a chronic inflammatory disease that predominantly affects the joints, leading to pain, stiffness, and irreversible joint damage. While conventional disease-modifying antirheumatic drugs (DMARDs) have been the mainstay of treatment, biologic agents have revolutionized RA management in recent decades. This article reviews the role of biologics in the treatment of RA, focusing on their efficacy, safety profile, and long-term impact. We explore the mechanisms of action, advantages over conventional therapies, and potential risks associated with biologics. Current clinical evidence supports the effectiveness of biologics in achieving remission and reducing disease progression, but their use requires careful monitoring due to potential adverse effects such as infections and malignancy. Additionally, the cost of biologic agents remains a concern, especially in resource-limited settings. Future research should focus on optimizing treatment regimens and exploring biosimilars as cost-effective alternatives.