Abstract

Use of Cladribine for multiple sclerosis treatment: An image article

Author(s): Jeniffer Stewert

Cladribine reaches the cell via proteins that hold nucleoside. Cladribine is activated within the cell by three subsequent phosphorylations, the first being deoxycytidine kinase. The enzyme 5'-nucleotidase (5'-NTase), active cladribine can be inactivated by dephosphorylation.