What is Childrens s Diabetic Keto Acidosis (DKA) Dynamic Insulin Dose?

Ahmad Abul Ainine

Consultant in Pediatrics, Diabetes & Endocrine, UK

Abstract

Background: Lancing children hourly to check blood glucose (BG) is sadly used to tune insulin dose rate in DKA. Insulin dose has many components; like age, body size, blood-sugar, sugar-intake, hydration and stress-levels. Finding insulin-component correlations help estimate total DKA dose. Luckily, DKA is a good opportunity to study insulin dosing in diabetes.

Aim: Finding BG/insulin correlation may help refine DKA management with least pricking, BG excursions and number of insulin dose changes.

Methods: To calculate various components of DKA insulin dose, and their correlations, to find the total insulin dose mathematically and compare with the doses used clinically. Biological variables like age, size, insulin & glycaemia …etc. will be identified. Pharmaco-kinetic principles would be applied to them. Their mathematical correlations equations will be derived for various ages.

Results: The DKA-components doses we found by regression analysis and added up for total dose. The equations were used in Dynamic DKA software programme. That helps to study quantitative roles of various bio-variables. Live interactive display would illustrate each.

Conclusion: The Dynamic DKA programme uses many bio-variables to instantly find their roles and total dose. Mathi-Medics can unravel the multifactorial diabetes control that may be applied in day-to-day care

Publications

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Toddlers’ diabetes: The lost insulin drop and SemiPens vs. DeciPen