Volume 1, Issue 1
Editorialp. 3
New oral anticoagulants for stroke prevention in atrial fibrillation
Author(s): John W Eikelboom, Jeffrey I Weitz
News and Viewsp. 9–12
US FDA approves trastuzumab for the treatment of HER2-positive metastatic stomach cancer
Clinical Trail Outcomesp. 13
Developing an international network for clinical research: the Community-Acquired Pneumonia Organization experience
Author(s): Paula Peyrani, Timothy Wiemken, Forest Arnold,Julio Ramirez
Review Articlep. 19
Design of clinical trials of antibacterial agents for community-acquired bacterial pneumonia
Author(s): Brad Spellberg, Roger J Lewis, Helen W Boucher,Eric P Brass
Review Articlep. 33
Early-phase oncology clinical trial design in the era of molecularly targeted therapy: pitfalls and progress
Author(s): Penelope Bradbury, John Hilton , Lesley Seymour
Review Articlep. 45
Ethical, clinical and practical considerations in designing clinical trials in pediatric psychopharmacology
Author(s): Philippe Auby
Review Articlep. 53
Data and safety monitoring boards of randomized trials: evolving principles and practical suggestions
Author(s): Charles H Hennekens,David DeMets4
Review Articlep. 59
Will preoperative trials change future clinical practice?
Author(s): Elgene Lima,Eric P Winer
Review Articlep. 75
Pazopanib in the treatment of renal cell carcinoma
Author(s): C Lance Cowey, Thomas E Hutson, Robert Figlin
Review Articlep. 87
Results and implications of the Trastuzumab for Gastric Cancer (ToGA) trial
Author(s): Dok Hyun Yoon1 & Yoon-Koo Kang
Review Articlep. 97
Bisphosphonates in the adjuvant treatment of breast cancer: rationale and clinical data
Author(s): Michael Gnant
Review Articlep. 109
Pharmacological treatment of endometriosis: update from recent clinical trials
Author(s): Simone Ferrero, Valentino ,Remorgida, Pier Luigi Venturini
Review Articlep. 119
Lacosamide as a new add-on therapy for the treatment of partial-onset seizures
Author(s): Steve S Chung
Review Articlep. 125
Emerging therapies in the management of hypertensive patients with osteoarthritis
Author(s): Giorgio Gentile, Fabio Angeli, Giovanni Mazzotta, Gianpaolo Reboldi , Paolo Verdecchia
Review Articlep. 137
The IMPROVE-IT trial: current status and potential clinical implications of ezetimibe
Author(s): Finn Akerstrm, Luis Rodriguez-Padial
Review Articlep. 145
Sodium,glucose cotransporter 2 inhibitors in the treatment of Type 2 diabetes: a review of Phase II and III trials
Author(s): Mark S Kipnes
Review Articlep. 157
Diabetes vaccines: review of the clinical evidence
Author(s): Johnny Ludvigsson
Review Articlep. 171
Long-term management of atopic dermatitis: evidence from recent clinical trials
Author(s): Sakari Reitamo ,Johanna M Mandelin, Anita Remitz
