Biosensing
The natural
biosensing molecules described above are often replaced by synthetic analogues which mimic functionality of the native unit. The synthetic
molecules include
peptide aptamers, oligonucleotide aptamer, DNA and oligonucleotide analogues, like
peptide nucleic acids (PNAs), locked nucleic acids (LNAs), glycol macromolecule (GNA), and threose macromolecule (TNA). A
peptide aptamer may be a short
peptide with high affinity to the target molecules, which makes them an alternate to an antibody. It's engineered by inserting an oligonucleotide-encoding aptamer into the
gene of the supporting protein.
Peptide aptamers are used for detection of food contamination, pathogen detection, medical diagnostics, and detection of
proteins, e.g., human chorionic gonadotropin. Their ability to acknowledge 3D structure of proteins they will be used rather than antibodies. The length of a typical oligonucleotide aptamer is typically 12–25-mer. Their stability and life-time are increased by chemical modifications of sugar-phosphate backbone.
High Impact List of Articles
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Clinical Pathological Analysis and Treatment of Iga Nephropathy with a Few Quantity of Renal Crescent Formation
John
Abstract: Journal of Interventional Nephrology
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Clinical Pathological Analysis and Treatment of Iga Nephropathy with a Few Quantity of Renal Crescent Formation
John
Abstract: Journal of Interventional Nephrology
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Prevalence of hepatitis B and C viruses infections among hemodialysis patients in Addis Ababa, Ethiopia
Juhar SK, Nurahmed N, Kebede S, Getahun M, Arega T & Abdi AM
Research Article: Journal of Interventional Nephrology
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Prevalence of hepatitis B and C viruses infections among hemodialysis patients in Addis Ababa, Ethiopia
Juhar SK, Nurahmed N, Kebede S, Getahun M, Arega T & Abdi AM
Research Article: Journal of Interventional Nephrology
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Analysis of internal jugular catheter (IJC) inserted by a nephrologist for haemodialysis in a kidney care center in Nigeria.
Okafor UH, Ezeala BA, Maeke B
Research Article: Journal of Interventional Nephrology
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Analysis of internal jugular catheter (IJC) inserted by a nephrologist for haemodialysis in a kidney care center in Nigeria.
Okafor UH, Ezeala BA, Maeke B
Research Article: Journal of Interventional Nephrology
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MicroRNA mediates CD8+ T cell dysfunction in chronic viral infection
Riyasat Ali*
Editorial: Research on Chronic Diseases
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MicroRNA mediates CD8+ T cell dysfunction in chronic viral infection
Riyasat Ali*
Editorial: Research on Chronic Diseases
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Autoimmune disease and mitochondrial dysfunction in chronic diseases
Martins IJ
Editorial: Research on Chronic Diseases
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Autoimmune disease and mitochondrial dysfunction in chronic diseases
Martins IJ
Editorial: Research on Chronic Diseases
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