Bone Biology

Bone may be a mineralized animal tissue that exhibits four sorts of cells: osteoblasts, bone lining cells, osteocytes, and osteoclasts. Bone exerts important functions within the body, like locomotion, support and protection of sentimental tissues, calcium and phosphate storage, and harboring of bone marrow. Despite its inert appearance, bone may be a highly dynamic organ that's continuously resorbed by osteoclasts and neoformed by osteoblasts. there's evidence that osteocytes act as mechanosensors and orchestrators of this bone remodeling process . This process occurs thanks to coordinated actions of osteoclasts, osteoblasts, osteocytes, and bone lining cells which together form the temporary structure called basic multicellular unit (BMU) . Normal bone remodeling is important for fracture healing and skeleton adaptation to mechanical use, also as for calcium homeostasis . On the opposite hand, an imbalance of bone resorption and formation leads to several bone diseases. The function of bone lining cells isn't well clear, but these cells seem to play a crucial role in coupling bone resorption to bone formation.Bone remodeling may be a highly complex process by which old bone is replaced by new bone, during a cycle comprised of three phases:initiation of bone resorption by osteoclasts, the transition (or reversal period) from resorption to new bone formation, and therefore the bone formation by osteoblasts .