CNS Inflammation
Inflammatory
brain disease, also referred to as inflammatory disease of the central nervous system is a condition where the
brain and/or
spinal cord become inflamed.
Inflammation in the
brain causes irritation and swelling of
brain tissue or blood vessels.
Brain inflammation can occur for a spread of reasons. How the vessels within the
brain become inflamed isn't entirely clear. In some vasculitic ailments, irregular antibodies (autoantibodies) assault white platelets, which assault vessel dividers and cause aggravation and pulverization of the vessel divider. Disease brought about by a plague additionally can cause CNS vasculitis. Aerobic exercise is employed widely to scale back
inflammation within the periphery. Exercise has been shown to decrease proliferation of microglia in the brain, decrease hippocampal expression of immune-related genes, and reduce expression of inflammatory cytokines such as TNF-α. There is an increasing recognition that
inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, and therefore the prototypic neuroinflammatory disease
multiple sclerosis (MS). Differential immune responses involving the adaptive versus the innate system are observed at various stages of
neurodegenerative diseases, and should not only drive disease processes but could serve as therapeutic targets. On-going investigations into the precise inflammatory mechanisms that play roles in disease causation and progression have revealed lessons about inflammation-driven
neurodegeneration which will be applied to other
neurodegenerative diseases. An increasing number of immunotherapeutic strategies that are successful in MS are now being applied to other
neurodegenerative diseases. Some approaches suppress CNS immune mechanisms, while others harness the system to clear deleterious products and cells. This Review focuses on the mechanisms by which inflammation, mediated either by the peripheral immune reaction or by endogenous CNS immune mechanisms, can affect CNS neurodegeneration.
High Impact List of Articles
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Improving patient participation in Parkinsons clinical trials: the experience of the Michael J Fox Foundation
Sohini Chowdhury, Claire C Meunier, Lily Cappelletti & Todd B Sherer
Clinical Trail Perspective: Clinical Investigation
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Improving patient participation in Parkinsons clinical trials: the experience of the Michael J Fox Foundation
Sohini Chowdhury, Claire C Meunier, Lily Cappelletti & Todd B Sherer
Clinical Trail Perspective: Clinical Investigation
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Chloroquine enjoys a renaissance as an antineoplastic therapy
Virginia Espina, Lance A Liotta
Therapeutic Prospective: Clinical Investigation
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Chloroquine enjoys a renaissance as an antineoplastic therapy
Virginia Espina, Lance A Liotta
Therapeutic Prospective: Clinical Investigation
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Emerging medical treatments for actinic keratoses, squamous cell carcinoma and basal cell carcinoma
Nasreen Ghuznavi, Nadia F Nocera, Andrew R Guajardo, Jeffrey M Weinberg
Review: Clinical Trail Outcomes: Clinical Investigation
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Emerging medical treatments for actinic keratoses, squamous cell carcinoma and basal cell carcinoma
Nasreen Ghuznavi, Nadia F Nocera, Andrew R Guajardo, Jeffrey M Weinberg
Review: Clinical Trail Outcomes: Clinical Investigation
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Crizotinib for the treatment of non-small-cell lung cancer with ALK gene rearrangements
Muhammad Alamgeer, Toni-Maree Rogers, Stephen B Fox, Benjamin Solomon
Review: Clinical Trail Outcomes: Clinical Investigation
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Crizotinib for the treatment of non-small-cell lung cancer with ALK gene rearrangements
Muhammad Alamgeer, Toni-Maree Rogers, Stephen B Fox, Benjamin Solomon
Review: Clinical Trail Outcomes: Clinical Investigation
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Alzheimers disease vaccines: promises and pitfalls
Takeshi Tabira
Therapeutic Prospective: Clinical Investigation
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Alzheimers disease vaccines: promises and pitfalls
Takeshi Tabira
Therapeutic Prospective: Clinical Investigation
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