ISSN: 2044-9038 (Print) 2044-9046 (Electronic)

Clinical Practice

Mechanosensitivity

 Muscle cells have certain structure, involving a developed cytoskeleton that takes up the larger part of the cell and which forms the contractile apparatus. This submembrane (cortical) cytoskeleton of muscle cells is usually same to the cortical cytoskeleton of nonmuscle cells, except for in some special points, that is in the estimate of M-line and Z-disc on the membrane. The mechanical system, the cell for example, in the external province is in tension (from a mechanical point of view), and as such the cell forms its internal and structure mechanical tension in accordance with the amplitude and vector of this external force. A change in the external force (either its vector or amplitude) will naturally cause a change in the mechanical tension of the cell and guide to its deformation. The level of consequences and significance, of these deformations on the needed activities of the cell will depend on the cell’s mechanical properties and the susceptibility of its mechanosensors.  

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