Journal of Cosmetic Science and Technology

Premature Ovarian Failure

 Primary ovarian insufficiency is also called as premature ovarian failure occurs when the ovaries stop functioning normally before age 40. the primary step in determining a POF diagnosis may be a biopsy to see whether or not the ovary is producing estrogen and if the pituitary gland is producing the hormones FSH and LH that stimulate the ovarian follicles. Irregularity of the menstrual cycle in the form of amenorrhoea or oligomenorrhoea is the main presenting feature. Signs and symptoms of primary ovarian insufficiency are almost like those of menopause or estrogen deficiency. They include: irregular or skipped periods, which could be present for years or develop after a pregnancy or after stopping contraception pills, difficulty getting pregnant, hot flashes, night sweats, vaginal dryness, dry eyes, irritability or difficulty concentrating, decreased concupiscence. The primary step in determining a POF diagnosis may be a biopsy to check whether or not the ovary is producing estrogen and if the pituitary gland is producing the hormones FSH and LH that stimulate the ovarian follicles. If the biopsy indicates elevated pituitary hormones and that the ovary isn't producing estrogen, then this is often a transparent sign of POF. Unfortunately, there's no proven method of stimulating the ovaries if POF is diagnosed.  

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