Prostaglandins
The
prostaglandins (PG) PG) area unit a gaggle of physiologically active lipide compounds known as
eicosanoids having numerous hormone-like effects in animals.
Prostaglandins are found in virtually each tissue in humans and different animals. they're derived enzymatically from the carboxylic acid arachidonic acid.Every autocoid contains twenty carbon atoms, together with a 5-carbon ring. they're a taxon of
eicosanoids and of the prostanoid category of carboxylic acid derivatives.
The structural variations between
prostaglandins account for his or her totally different biological activities. A given autocoid might have totally different and even opposite effects in several
tissues in some cases. the flexibility of an equivalent autocoid to stimulate a reaction in one tissue and inhibit an equivalent reaction in another tissue is decided by the kind of receptor to that the autocoid binds. They act as autocrine or paracrine factors with their target
cells gift within the immediate neighbourhood of the location of their secretion.
Prostaglandins dissent from endocrine
hormones in this they're not created at a selected website however in several places throughout the figure.
Prostaglandins area unit powerful, locally-acting vasodilators and inhibit the aggregation of blood platelets. Through their role in dilation,
prostaglandins also are concerned in inflammation. they're synthesized within the walls of blood vessels and serve the physiological perform of preventing gratuitous clot formation, also as regulation the contraction of sleek muscle tissue. Conversely, thromboxanes (produced by protoplasm|thrombocyte|protoplasm|living substance} cells) area unit vasoconstrictors and facilitate platelet aggregation. Their name comes from their role in clot formation (thrombosis).
High Impact List of Articles
Relevant Topics in Medical