ISSN: 1755-5310 (Electronic)1755-5302 (Print)

Interventional Cardiology

Proteomics Technologies

 Proteomics is that the protein equivalent of genomics and has captured the imagination of biomolecular scientists worldwide. Proteomics encompasses a broad range of technologies aimed toward determining the identity and quantity of expressed proteins in cells, their three-dimensional structure and interaction partners. Because proteome reflects more accurately on the dynamic state of a cell, tissue, or organism, we are able to predict much from proteomics to yield better disease markers for diagnosis and therapy monitoring. the arrival of proteomics technologies for global detection and quantitation of proteins creates new opportunities and challenges for those seeking to realize greater understanding of diseases. High-throughput proteomics technologies combining with advanced bioinformatics are extensively utilized to identify molecular signatures of diseases based on protein pathways and signaling cascades. Various technologies include: Chromatography based techniques, Enzyme linked immunosorbent assay, We3stern Blotting, Edman sequencing and many more. Mass spectrometry plays an important role in proteomics and has become an important tool for molecular and cellular biology. Over three decades, 2-D PAGE has proven to be a reliable and efficient method for separation of proteins based on mass and charge. It are able to do the separation of several thousand different proteins in one gel. combination of those technologies has achieved success in purification, analysis, characterization, quantification, sequence and structural analysis and bioinformatics analysis of huge number of proteins altogether sorts of eukaryotic and prokaryotic organisms. All fields associated with biological sciences are benefited with increasing use of proteomics techniques.  

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