Radiochemotherapy
Radio (chemo)therapy has been a crucial a part of
carcinoma treatment for several decades and its recent advances have led to significant improvements in treatment outcomes. The present review will specialise in the appliance of
radiotherapy for locally advanced nonsmall cell
carcinoma (NSCLC).
Carcinoma is one among the foremost common causes of
cancer death, with many patients diagnosed during a locally advanced stage. Although the treatment outcome has improved over the last decades, it remains poor. Locally advanced
carcinoma may be a heterogeneous group and therefore the definition often overlaps with stage III carcinoma. Typically patients with stage I/II
carcinoma would be primarily considered for curatively intended
surgery or stereotactic body
radiotherapy just in case of inoperability. Stage IV patients would typically receive palliative treatment, often involving systemic agents while nowadays multimodal concepts are being tested in oligo-metastatic cases.
Radiotherapy delivers ionising radiation, which successively causes physical and chemical interactions resulting in DNA and other tumour damage. Repetitive exposure to appropriate doses of radiation causes increased damage to tumour
cells in comparison to healthy tissue. this is often the idea of conventionally fractionated radiotherapy, where typically a dose of two Gy is delivered five times per week. Currently a daily fraction of 1.8–2 Gy is taken into account standard for carcinoma.
High Impact List of Articles
-
New guidelines for hormone-replacement therapy: An update on risks and benefits for clinical practice
H Hamoda, M Savvas, N Panay
Editorial: Clinical Practice
-
New guidelines for hormone-replacement therapy: An update on risks and benefits for clinical practice
H Hamoda, M Savvas, N Panay
Editorial: Clinical Practice
-
Evaluating treatments of borderline personality disorder
Robert S Biskin and Joel Paris
Review Article: Clinical Practice
-
Evaluating treatments of borderline personality disorder
Robert S Biskin and Joel Paris
Review Article: Clinical Practice
-
Highlights from the latest articles in cystic fibrosis clinical and translational sciences
Pamela L Zeitlin
Research Highlights: Clinical Practice
-
Highlights from the latest articles in cystic fibrosis clinical and translational sciences
Pamela L Zeitlin
Research Highlights: Clinical Practice
-
Glycemic control and cardiovascular disease in a high-risk chronic kidney disease population
Rachandeep Singh, Ravi Nistala, Samy I McFarlane and Adam Whaley-Connell
Review Article: Clinical Practice
-
Glycemic control and cardiovascular disease in a high-risk chronic kidney disease population
Rachandeep Singh, Ravi Nistala, Samy I McFarlane and Adam Whaley-Connell
Review Article: Clinical Practice
-
Pharmacotherapy of obesity
Kostas Lois and Sudhesh Kumar
Review Article: Clinical Practice
-
Pharmacotherapy of obesity
Kostas Lois and Sudhesh Kumar
Review Article: Clinical Practice
-
TGF-β signaling dictates therapeutic targeting in prostate cancer
Natasha Kyprianou
Editorial: Clinical Practice
-
TGF-β signaling dictates therapeutic targeting in prostate cancer
Natasha Kyprianou
Editorial: Clinical Practice
-
Profile of azacitidine
Francsco D\'Alo, Maria Teresa Voso and Giuseppe Leone
Drug Evaluation: Clinical Practice
-
Profile of azacitidine
Francsco D\'Alo, Maria Teresa Voso and Giuseppe Leone
Drug Evaluation: Clinical Practice
Relevant Topics in Clinical